‘Young’ blood may hold key to age reversal
NEW YORK—Older mice got stronger, exercised longer and performed better mentally after they were injected with blood from young mice, or even just with a substance that’s more abundant in younger blood, US researchers found.
Someday, if more research goes well, this may lead to a way to treat some infirmities of old age in people. In the meantime, scientists have a warning for do-it-yourselfers.
“Don’t try this at home,” said Saul Villeda of the University of California, San Francisco, an author of one of three papers published online on Sunday by the journals Nature Medicine and Science.
Villeda worked with mice that were roughly the equivalent of people in their 20s and 60s.
In the three studies, researchers repeatedly injected the older mice with blood from either the younger animals or other aged mice.
Those that got the young blood did better in learning and memory tests than the mice given the older blood. For example, they performed better at recalling where to find a submerged platform in a maze.
The researchers, according to Villeda, are trying to figure out what is in the young blood that made the difference.
GDF11 protein
The two other research papers, from Harvard University, focused on a substance that is more abundant in the blood of younger mice than old.
That protein, called GDF11, is also found in human blood and its concentration also appears to decline with age, said Amy Wagers, an author on both papers.
On average, aging mice that got injections of GDF11 showed greater grip strength and more endurance on a treadmill than untreated mice.
The Harvard scientists also found that exposing older mice to the blood of younger mice produced more blood vessels and blood flow in the brain. Injections of GDF11 had a similar effect.
Lee Rubin, a study author, said those results suggested further work may lead to a way to treat age-related mental decline and perhaps dementia in people.
Even so, Wagers and Villeda said it remained unclear whether GDF11 explained the results of Villeda’s study. Wagers said she suspected other substances in blood could also help aging animals.
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