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Accidental find shows Vitamin C kills tuberculosis

AFP file photo

PARIS — Scientists said Tuesday they had managed to kill lab-grown tuberculosis (TB) bacteria with good old Vitamin C — an “unexpected” discovery they hope will lead to better, cheaper drugs.

A team from Albert Einstein College of Medicine in New York made the accidental find while researching how TB bacteria become resistant to the TB drug isoniazid.

The researchers added isoniazid and a “reducing agent” known as cysteine to the TB in a test tube, expecting the bacteria to develop drug resistance.

Instead, the team “ended up killing off the culture”, according to the study’s senior author William Jacobs, who said the result was “totally unexpected.”

Reducing agents chemically reduce other substances.

The team then replaced the cysteine in the experiment with another reducing agent — Vitamin C.

It, too, killed the bacteria.

“I was in disbelief,” said Jacobs of the outcome published in the journal Nature Communications.

“Even more surprisingly… when we left out the TB drug isoniazid and just had Vitamin C alone, we discovered that Vitamin C kills tuberculosis.”

The team next tested the vitamin on drug resistant strains of TB, with the same outcome.

In the lab tests, the bacteria never developed resistance to Vitamin C — “almost like the dream drug”, Jacobs said in a video released by the college.

He stressed the effect had only been demonstrated in a test tube so far, and “we don’t know if it will work in humans,” or which dose might be useful.

“But in fact before this study we wouldn’t have even thought about trying this study in humans.”

In March, disease experts warned of a “very real” risk of an untreatable TB strain emerging as more and more people develop drug resistance.

In 2011, there were believed to be some 12 million TB cases in total — 630,000 of them of the multi-drug resistant (MDR) variety which does not respond to the most potent drugs — isoniazid and rifampin.

Extensively drug resistant (XDR) TB, does not respond to an even wider range of drugs.

TB was declared a global health emergency by the World Health Organization (WHO) 20 years ago, but remains a leading cause of death by an infectious disease despite a 41-percent drop in the death rate from 1990 to 2011.

In 2011, 8.7 million people fell ill with TB and 1.4 million died, said the WHO.

Over 95 percent of TB deaths occur in low- and middle-income countries, and it is a leading killer of people with HIV.

An airborne disease of the lungs, tuberculosis is usually treatable with a six-month course of antibiotics.

Resistance to TB drugs develops when treatment fails to kill the bacterium that causes it — either because the patient fails to follow their prescribed dosages or the drug doesn’t work.

It can also be contracted through rare forms of the disease that are directly transmissible from person to person.

MDR TB in the United States can cost as much as $250,000 (200,000 euros) per patient to treat.

XDR TB requires about two years of treatment with even more expensive drugs that cause side-effects and offer no guarantee of a cure.

The authors of the new study urged further research into the potential uses of Vitamin C in TB treatment, stressing it was “inexpensive, widely available and very safe to use.”

“This would be a great study to consider because we have strains of tuberculosis that we don’t have drugs for, and I know in the laboratory that we can kill those strains with Vitamin C,” said Jacobs.

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Tags: Disease , Health , treatment , Tuberculosis , Vitamin C

  • WeAry_Bat

    Hahaha, natural is best always.

  • turniphouse

    sa probinsya daming fresh, sa paligid lang marami na. paano kasi dito nagsisiksikan sa siyudad. sariwa pa hangin dun. kaya ang TB laganap sa mga crowded areas kasi nga siksikan at ang hangin contaminated.

  • muddygoose

    The best source would be unprocessed foods, including raw fish or meat. Problem is most poor people do not get access to fresh, clean food products.

  • http://www.facebook.com/people/Stun-Black/100000220370803 Stun Black

    kalamansi juice lang na maraming bawang at sibuyas.

  • regd

    I KNEW IT! Suspetsa ko na ang Vit C even in high dosage can cure TB noon pa. Now if only my father will start agreeing with me on this, otherwise I will spike his drinks with this stuff. Good article, good stuff.

    • clarissa montes

      Hu? Sa mikrobyong tb yes pwede syang pumatay. Pero ibang usapan kung angtableta ay iinumin na ng tao. Madaming dinadaanan yan, tulad ng tyan, bituka, atay. Hindi naman ganun yan kadali. Hanggat hindi ito nagkakaroon ng trial sa mga taong may tb at umiinom ng vitamin C, hindi ito pwede pang gamitin. Promising pwede, pero malayo pa ang lalakbayin.

      • regd

        Oh, ok. ganun pala. Thanks.

  • korikong3

    ayaw ng mga drug companies nyan. Isipin mo billion nagastos nila sa research prutas lang pala ang papatay sa mga bacteria na yan. Lugi sila. wala ng bibili ng gamot nila.

    • Jose Laxa

      Tama ka dyan. Sa expericen ko sa pag-gym, plain Vit C lang (yung mura) ang iniinom ko araw-araw, walang iba-bang food supplements at sa awa ng Diyos walang grabeng sakit ang nangyayari akin.

      Vitamin C – para sa power lifter at muscle builder.

      • korikong3

        I know somebody who is in his 60′s got cured of his liver CA by drinking pure calamansi juice everyday.

    • batangpaslit

      matagal nang alam natin ‘yan na good nutrition and plenty of fruits rich in Vit C is kontra sipon at kontra TB
      you are right, the commercial pharmacological firms would hate this publication.
      these firms do not really care for the patients. they only care in making outrageous profits from sick people.

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